Methylene Blue Becomes an Exciting and Potential аѕ Antі-аgіng Treatment

Methylene blue is a low-cost and common antioxidant that has been useful for the clinical treatment for different diseases. Recently, it was discovered to have anti-aging properties. Scientists at the University of Maryland have started conducting more research on the effect of methylene blue on the skin. Their research showed that it has the ability to decrease and also reverse obvious signs of aging in human skin cells and artificial skin tissue in culture. Their findings have been published in Scientific Reports.

Kan Cao; an associate professor of Cell Biology and Molecular Genetics at UMD said: “Our work suggests that methylene blue could be a powerful antioxidant for use in skin care products, the effects we are seeing are not temporary. Methylene blue appears to make fundamental, long-term changes to skin cells.”

The scientists experimented on both healthy and unhealthy skin cells from investigators exposed healthy and diseased skin cells from middle-aged patients by exposing the cells to methylene blue and three extra antioxidants. They found that the methylene improved the symptoms of aging in both cell types more than the other antioxidants. The unhealthy cells were affected by progeria, a disease that quickens aging in humans. The scientists detected a decrease in cell death, shrinkage in deleterious relative oxygen species, and a rise in cell division in the skin cells, fibroblasts.

Cao and her team also exposed fibroblasts from people over age 80 to methylene blue for a period of four weeks and also noticed improvements. The scientist noticed a decrease in the expression of two genes mostly used to identify aging in cells, senescence-associated beta-galactosidase and p16.

The lead author Zheng-Mei Xiong who is also an Assistant Research Professor of Cell Biology and Molecular Genetics at UMD said; “I was encouraged and excited to see skin fibroblasts, derived from individuals more than 80 years old, grow much better in methylene blue-containing medium with reduced cellular senescence markers. Methylene blue demonstrates a great potential to delay skin aging for all ages.”

Cao and Xiong have made a model that mimics the three-dimensional structure of skin including the chief structures and layers of the skin, except the hair follicles and sweat glands. The scientist noted this model which can be used in testing as required by the Food and Drug Administration and some extra work in the report.

Cao said; “This system allowed us to test a range of aging symptoms that we can’t replicate in cultured cells alone, most surprisingly, we saw that model skin treated with methylene blue retained more water and increased in thickness–both of which are features typical of younger skin.”

Cao, Xiong and their colleagues were also encouraged by the testing they did on cosmetic creams that had methylene blue because they exhibited little signs that irritation was happening.

“We have already begun formulating cosmetics that contain methylene blue. Now we are looking to translate this into marketable products. We are also very excited to develop the three-dimensional skin model system. Perhaps down the road we can customize the system with bio printing, such that we might be able to use a patient’s own cells to provide a tailor-made testing platform specific to their needs,” Cao concluded.

Category: Beauty Tips